Combining PRP with Different Filler Brands: What Works Best?

Combining Platelet-Rich Plasma (PRP) with dermal fillers is a sophisticated approach in aesthetic medicine that leverages the healing and regenerative properties of PRP to enhance the cosmetic effects of fillers. Each brand and type of filler has unique characteristics, and some may synergize better with PRP than others. The effectiveness of combining PRP with different brands of fillers depends largely on the composition of the filler, the specific treatment goals, and individual patient factors. Here’s an overview of how PRP might interact with various popular filler brands:

Hyaluronic Acid Fillers:

Hyaluronic acid (HA) fillers are the most commonly used with PRP because they are well tolerated and have a high safety profile.Filler Injections with PRP Islamabad, Rawalpindi & Pakistan Brands like Juvederm, Restylane, and Belotero are known for their range of products that can treat everything from fine lines to deep volume loss.

Juvederm: Offers a variety of formulations which can be selected based on the treatment area’s needs. For example, Juvederm Voluma is excellent for adding volume to cheeks, which can be further enhanced by the regenerative capabilities of PRP.

Restylane: Similar to Juvederm, Restylane has options like Restylane Lyft for deeper injections and volume, and Restylane Silk for finer lines and more delicate areas. PRP can help improve the skin’s texture and tone when used in conjunction with these fillers.

Belotero: Known for its ability to integrate into the skin and provide very natural results, making it a good choice for combining with PRP, particularly for superficial lines and areas requiring a subtle touch.

Calcium Hydroxylapatite Fillers:

Radiesse is a popular calcium hydroxylapatite filler that not only provides immediate volume but also stimulates the body’s natural collagen production. When combined with PRP, which itself promotes tissue regeneration and healing, the effects can be synergistic, especially in areas requiring significant structural support like the jawline and cheeks.

Poly-L-lactic Acid Fillers:

Sculptra is designed for gradual and long-lasting results as it stimulates the body to produce its own collagen. When used with PRP, the initial boost in collagen synthesis from Sculptra can be enhanced by the growth factors released by PRP, potentially leading to more durable and pronounced effects.

Polymethylmethacrylate (PMMA) Fillers:

Bellafill is a PMMA filler that offers permanent results due to its non-resorbable microspheres. While it can provide long-term structural support, the permanent nature of Bellafill makes it crucial to use with PRP under expert guidance only, as any errors in application are not easily correctable.

Choosing the Right Combination:

The choice of filler brand and type should be based on:

Treatment Area: Different fillers are better suited to different areas of the face, depending on the thickness of the product and the desired volume or lift.

Desired Longevity: Products like Sculptra or Radiesse may offer longer-lasting results than HA fillers but are generally slower to show effects.

Patient’s Skin Type and Condition: The condition of the patient’s skin, their age, and their overall health can influence how well they respond to PRP and fillers.

Expertise of the Practitioner: Always consult with a skilled practitioner who understands both the art and science of combining PRP with various fillers. They should have a thorough understanding of facial anatomy and the properties of each filler option.


While there’s no definitive “best” brand or type of filler to use with PRP, the combination should be tailored to each individual’s needs and the specific characteristics of their skin. Consultation with a seasoned professional who can assess these variables will ensure the best aesthetic outcome.

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